The park is situated in the tourist region of the Red Sea Riviera, located 12 km from the city of Sharm El Sheikh. The park spans an area of 480 km², including 135 km² of surface land area and 345 km² area over water. Marsa Bareika is a small bay inlet in Ras Mohammed, and Marsa Ghozlani is a small inlet located across from the park visitors’ centre.
Ras Mohammad encompasses two islands, Tiran and Sanafir. Tiran Island is located approximately 6 km offshore from the Sinai Peninsula. Underwater caves formed as the result of earthquakes are in Ras Mohammad.
About 0.9 hectare of mangrove forest cover a 1.16 km shallow channel at the southernmost end of Ras Mohammad peninsula. Near the mangrove and approximately 150m inland, there are open cracks in the land, caused by earthquakes. One of the cracks is approximately 40m length and 0.20−1.5m in width. Within the cracks, there are pools of water, some with a depth of over 14m.
The inland area includes a diversity of desert habitats such as mountains and wadis, gravel and coastal mud plains and sand dunes. The area also plays a role in bird migration, serving as a place of rest and nourishment.
Ras Mohammad National Park experiences a very dry climate, with only minimal rainfall during the winter. During the summer, temperatures often exceed 40°C and low temperatures around 27°C. Temperatures are mild during the winter, with daytime high temperatures averaging around 23°C and low temperatures 14°C.
Coral reef, of the fringing and hermatypic types, exist along the coast around Ras Mohammad close to the shoreline. More than 220 species of coral are found in the Ras Mohammad area, 125 of them soft coral. The coral reefs are located 50 to 100cm below the sea surface, and they have a width of 30 to 50 m in most places. Though in some spots on the western coast, the coral reef is 8 to 9km wide. Shark Reef and Yolanda Reef are popular areas of coral reef in the park for divers. Other coral reef sites include South Bereika, Marsa Ghozlani, Old Quay, and Shark Observatory. The wreckage of the SS Thistlegorm, located off the coast of Ras Mohammad, is a popular area for divers.
The area is home to more than 1,000 species of fish, 40 species of star fish, 25 species of sea urchins, more than a 100 species of mollusc and 150 species of crustaceans. Among others, sea turtles, such as the green turtle (Chelonia mydas) and the hawksbill turtle (Eretmochelys imbricata) appear regularly in Ras Mohammad.